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A Programmable Dual-RNA-Guided DNA Endonuclease

papers articles scientific paper paper major planned

Creators

  • Martin Jinek, author
  • Krzysztof Chylinski, author
  • Ines Fonfara, author
  • Michael Hauer, author
  • Jennifer A. Doudna, author
  • Emmanuelle Charpentier, author

Canon Rationale

A major CRISPR-Cas9 paper, included for programmable RNA-guided DNA cleavage and the modern genome-editing turn.

Evidence

  • citation context: Jinek et al., 'A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity,' Science, 2012.
  • field survey: The Nobel Prize, CRISPR-Cas9 chemistry prize scientific background, 2020.

Audit Flags

version dependency, epistemic status required

Completion unit: read the full 2012 Science paper.

Reading Lists